Cost-effective and customizable (E)-o-chlorocinnamic acid 939-58-2 in stock
- Molecular Formula: C9H7ClO2
- Molecular Weight: 182.606
- Melting Point: 212°C
- Refractive Index: 1.5426 (estimate)
- Boiling Point: 321.6°Cat760mmHg
- PKA: 4.29±0.10(Predicted)
- Flash Point: 148.3°C
- PSA： 37.30000
- Density: 1.332g/cm3
- LogP: 2.43780
(E)-o-chlorocinnamic acid(Cas 939-58-2) Usage
|
General Description |
(E)-o-chlorocinnamic acid is a chemical compound with the molecular formula C9H7ClO2. It is a derivative of cinnamic acid, with the chlorine atom positioned at the ortho position of the phenyl ring. (E)-o-chlorocinnamic acid is widely used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and organic materials. It is also used in the production of fragrances and flavors. (E)-o-chlorocinnamic acid is known for its pale yellow color and is sparingly soluble in water but soluble in organic solvents. It is an important building block in organic synthesis and is often utilized in the preparation of various chemical compounds. |
InChI:InChI=1/C9H7ClO2/c10-8-4-2-1-3-7(8)5-6-9(11)12/h1-6H,(H,11,12)/b6-5+
939-58-2 Relevant articles
Design, Synthesis, and Anticancer Activity of Cinnamoylated Barbituric Acid Derivatives
Liu, Yue,Li, Peng-Xiao,Mu, Wen-Wen,Sun, Ya-Lei,Liu, Ren-Min,Yang, Jie,Liu, Guo-Yun
, (2022/01/13)
This work deals with the design and synt...
Discovery of Novel Benzothiazepinones as Irreversible Covalent Glycogen Synthase Kinase 3β Inhibitors for the Treatment of Acute Promyelocytic Leukemia
Zhang, Peng,Min, Zhihui,Gao, Yang,Bian, Jiang,Lin, Xin,He, Jie,Ye, Deyong,Li, Yilin,Peng, Chao,Cheng, Yunfeng,Chu, Yong
, p. 7341 - 7358 (2021/06/28)
Recently, irreversible inhibitors have a...
Design, synthesis, and evaluation of different scaffold derivatives against NS2B-NS3 protease of dengue virus
Ganji, Lata R.,Gandhi, Lekha,Musturi, Venkataramana,Kanyalkar, Meena A.
, p. 285 - 301 (2020/11/19)
The number of deaths or critical health ...
Dual Nickel/Ruthenium Strategy for Photoinduced Decarboxylative Cross-Coupling of α,β-Unsaturated Carboxylic Acids with Cycloketone Oxime Esters
Gao, Ang,Jiang, Run-Chuang,Liu, Chuang-Chuang,Liu, Qi-Le,Lu, Xiao-Yu,Xia, Ze-Jie
supporting information, p. 8829 - 8842 (2021/06/30)
Herein, a dual nickel/ruthenium strategy...
939-58-2 Process route
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-
68208-20-8,740794-79-0
3-amino-3-(2-chloro-phenyl)-propionic acid
-
-
740794-79-0
(R)-3-amino-3-(2-chlorophenyl)propionic acid
-
-
704-96-1,939-58-2
trans-2-chlorocinnamic acid
-
-
103616-89-3,80126-50-7
(2S)-2-amino-3-(2-chlorophenyl)propanoic acid
| Conditions | Yield |
|---|---|
|
With
phenylalanine 2,3-aminomutase from Pantoea agglomerans; ammonium carbonate;
at 20 ℃;
for 20h;
pH=8;
enantioselective reaction;
Enzymatic reaction;
|
> 98 % ee
|
|
With
phenylalanine ammonia α-lyase from Anabaena variabilis; phenylalanine ammonia lyase from Streptomyces maritimus;
In
aq. buffer;
at 30 ℃;
for 24h;
pH=8;
Reagent/catalyst;
enantioselective reaction;
Resolution of racemate;
Enzymatic reaction;
|
-
-
141-82-2
malonic acid
-
-
89-98-5
2-chloro-benzaldehyde
-
-
3752-25-8,939-58-2
o-chlorocinnamic acid
| Conditions | Yield |
|---|---|
|
With
piperidine; pyridine;
for 2h;
Reflux;
|
93%
|
|
malonic acid;
With
triethylamine;
In
toluene;
2-chloro-benzaldehyde;
With
piperidine;
In
toluene;
for 2h;
Reflux;
|
89%
|
|
With
piperidine;
In
pyridine;
for 1h;
Heating;
Darkness;
|
83%
|
|
With
piperidine; pyridine;
at 80 ℃;
for 1h;
|
83%
|
|
With
piperidine; pyridine;
at 60 - 120 ℃;
|
80%
|
|
With
piperidine;
for 0.00416667h;
microwave irradiation;
|
78%
|
|
|
|
|
malonic acid; 2-chloro-benzaldehyde;
With
piperidine; pyridine;
Reflux;
With
hydrogenchloride;
In
water;
at 25 ℃;
|
|
|
With
piperidine; pyridine;
at 80 - 90 ℃;
for 24h;
|
|
|
With
piperidine; pyridine;
at 100 - 120 ℃;
for 10h;
|
|
|
With
piperidine; pyridine;
for 6h;
Reflux;
|
|
|
With
piperidine;
In
dimethyl sulfoxide;
at 100 ℃;
for 12h;
Schlenk technique;
|
|
|
With
piperidine; pyridine;
at 20 - 90 ℃;
|
|
|
With
piperidine; triethylamine;
In
toluene;
for 2 - 3h;
Reflux;
|
|
|
malonic acid;
With
pyridine;
at 110 ℃;
2-chloro-benzaldehyde;
With
piperidine;
In
ethanol;
at 24 ℃;
Reflux;
|
|
|
With
piperidine; pyridine;
for 2h;
Inert atmosphere;
Schlenk technique;
Reflux;
|
|
|
With
piperidine; pyridine;
for 2h;
Reflux;
Schlenk technique;
Inert atmosphere;
|
939-58-2 Upstream products
-
20851-50-7
2-(2-chlorobenzylidene)malonic acid
-
1664-63-7
2-amino-cinnamic acid
-
24654-07-7
(2RS,3SR)-2,3-dibromo-3-(2-chlorophenyl)propanoic acid
-
7732-18-5
water
939-58-2 Downstream products
-
1643-28-3
3-(2-chlorophenyl)propanoic acid
-
24393-51-9
(E)-ethyl 2-chlorocinnamate
-
704-96-1
trans-2-chlorocinnamic acid
-
62640-63-5
2-chloro-2'-methoxystilbene
