Bulk supply high purity 3-[(4,5-dichloro-2-nitrophenyl)amino]propan-1-ol 62780-67-0, Paid sample available
- Molecular Formula: C9H10 Cl2 N2 O3
- Molecular Weight: 265.096
- Vapor Pressure: 1.58E-09mmHg at 25°C
- Boiling Point: 467.1°C at 760 mmHg
- Flash Point: 236.3°C
- PSA： 78.08000
- Density: 1.513g/cm3
- LogP: 3.29210
3-[(4,5-dichloro-2-nitrophenyl)amino]propan-1-ol(Cas 62780-67-0) Usage
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General Description |
3-[(4,5-dichloro-2-nitrophenyl)amino]propan-1-ol, also known as amiodarone, is a pharmaceutical compound with antiarrhythmic properties. It is a synthetic compound derived from a benzofuran derivative and acts by blocking potassium, sodium, and calcium channels in cardiac cells, thereby prolonging the action potential and refractory period. This helps to stabilize the rhythm of the heart and treat various types of arrhythmias. Amiodarone is commonly used in the treatment of ventricular and supraventricular arrhythmias, and it is known for its long half-life and potential for serious side effects, including pulmonary toxicity, thyroid dysfunction, and liver toxicity. Due to its complex pharmacokinetics and potential for adverse effects, amiodarone requires close monitoring and careful dosing by healthcare professionals. |
InChI:InChI=1/C9H10Cl2N2O3/c10-6-4-8(12-2-1-3-14)9(13(15)16)5-7(6)11/h4-5,12,14H,1-3H2
62780-67-0 Relevant articles
Discovery of a novel B-cell lymphoma 6 (BCL6)–corepressor interaction inhibitor by utilizing structure-based drug design
Yasui, Takeshi,Yamamoto, Takeshi,Sakai, Nozomu,Asano, Kouhei,Takai, Takafumi,Yoshitomi, Yayoi,Davis, Melinda,Takagi, Terufumi,Sakamoto, Kotaro,Sogabe, Satoshi,Kamada, Yusuke,Lane, Weston,Snell, Gyorgy,Iwata, Masashi,Goto, Masayuki,Inooka, Hiroshi,Sakamoto, Jun-ichi,Nakada, Yoshihisa,Imaeda, Yasuhiro
, p. 4876 - 4886 (2017)
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-
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Compounds of the class of 1-(benzazolyal...
62780-67-0 Process route
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-
2339-78-8
1,2-dichloro-4-fluoro-5-nitrobenzene
-
-
156-87-6
propan-1-ol-3-amine
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![3-[(4,5-dichloro-2-nitrophenyl)amino]-1-propanol](/upload/2026/4/9608ce1c1e704b91a6e013ebfa329b69_89542dec-b7d5-46a1-878f-5c49e6f3eb25.png)
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62780-67-0
3-[(4,5-dichloro-2-nitrophenyl)amino]-1-propanol
| Conditions | Yield |
|---|---|
|
With
N-ethyl-N,N-diisopropylamine;
In
N,N-dimethyl acetamide;
at 20 ℃;
|
89%
|
-
-
67-66-3,8013-54-5
chloroform
-
-
89-69-0
2,4,5-Trichloronitrobenzene
-
-
156-87-6
propan-1-ol-3-amine
-
-
62780-67-0
3-[(4,5-dichloro-2-nitrophenyl)amino]-1-propanol
| Conditions | Yield |
|---|---|
|
With
potassium iodide;
In
di-isopropyl ether; water; butan-1-ol;
|
|
|
With
potassium iodide;
In
di-isopropyl ether; water; butan-1-ol;
|
62780-67-0 Upstream products
-
89-69-0
2,4,5-Trichloronitrobenzene
-
156-87-6
propan-1-ol-3-amine
-
67-66-3
chloroform
-
2339-78-8
1,2-dichloro-4-fluoro-5-nitrobenzene
